Quantitative immunogold evidence that glutamate is a neurotransmitter in afferent synaptic terminals within the isthmo-optic nucleus of the pigeon centrifugal visual system
Identifieur interne : 003454 ( Main/Exploration ); précédent : 003453; suivant : 003455Quantitative immunogold evidence that glutamate is a neurotransmitter in afferent synaptic terminals within the isthmo-optic nucleus of the pigeon centrifugal visual system
Auteurs : Dom Miceli [Canada] ; Jacques Repérant [Canada] ; Jean-Paul Rio [France] ; Jean Désilets [Canada] ; Monique Médina [France]Source :
- Brain Research [ 0006-8993 ] ; 2000.
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Abstract
A quantitative electron microscopic analysis of glutamate (GLU) immunoreactivity using the post-embedding immunogold technique was carried out within the isthmo-optic nucleus (ION) of the pigeon centrifugal visual system (CVS). Measurements were performed in each of eight different categories of axon terminals, including those that were GABA-immunoreactive (-ir), considered representing control profiles and identified using a single or double-label immunocytochemical procedure. The results demonstrated that the glutamate immunogold particle densities for both mitochondrial and vesicular pools and for total surface area of bouton profiles were significantly higher in P1a, P1b and P2b terminals and not significantly different in P4 and P5 terminals compared to those recorded in control GABA-ir terminals (P2a, P2c, P3). Moreover, the values measured in GLU-ir positive profiles were all significantly higher than in either P4 or P5 terminals. The results suggest that tectal neurons, which provide the main input to the ION cells, are either inhibitory GABA-ir possibly associated with P2c and/or P3 terminals or excitatory GLU-ir via P1a, P1b and P2b terminals. Such differential effects of tectal afferents may be the basis for the modulation of centrifugal activity and consequently of end target retinal ganglion cell responses. The data are relevant to hypotheses implicating the avian CVS in mechanisms of selective enhancement of visual attention to either novel or meaningful stimuli within the visual field.
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DOI: 10.1016/S0006-8993(00)02316-7
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to="134">134</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Afferent synaptic terminals</term><term>Centrifugal visual system</term><term>Electron microscopy</term><term>Glutamate immunoreactivity</term><term>Isthmo-optic nucleus</term><term>Pigeon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A quantitative electron microscopic analysis of glutamate (GLU) immunoreactivity using the post-embedding immunogold technique was carried out within the isthmo-optic nucleus (ION) of the pigeon centrifugal visual system (CVS). Measurements were performed in each of eight different categories of axon terminals, including those that were GABA-immunoreactive (-ir), considered representing control profiles and identified using a single or double-label immunocytochemical procedure. The results demonstrated that the glutamate immunogold particle densities for both mitochondrial and vesicular pools and for total surface area of bouton profiles were significantly higher in P1a, P1b and P2b terminals and not significantly different in P4 and P5 terminals compared to those recorded in control GABA-ir terminals (P2a, P2c, P3). Moreover, the values measured in GLU-ir positive profiles were all significantly higher than in either P4 or P5 terminals. The results suggest that tectal neurons, which provide the main input to the ION cells, are either inhibitory GABA-ir possibly associated with P2c and/or P3 terminals or excitatory GLU-ir via P1a, P1b and P2b terminals. Such differential effects of tectal afferents may be the basis for the modulation of centrifugal activity and consequently of end target retinal ganglion cell responses. The data are relevant to hypotheses implicating the avian CVS in mechanisms of selective enhancement of visual attention to either novel or meaningful stimuli within the visual field.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Miceli, Dom" sort="Miceli, Dom" uniqKey="Miceli D" first="Dom" last="Miceli">Dom Miceli</name></noRegion><name sortKey="Desilets, Jean" sort="Desilets, Jean" uniqKey="Desilets J" first="Jean" last="Désilets">Jean Désilets</name><name sortKey="Reperant, Jacques" sort="Reperant, Jacques" uniqKey="Reperant J" first="Jacques" last="Repérant">Jacques Repérant</name></country><country name="France"><noRegion><name sortKey="Rio, Jean Paul" sort="Rio, Jean Paul" uniqKey="Rio J" first="Jean-Paul" last="Rio">Jean-Paul Rio</name></noRegion><name sortKey="Medina, Monique" sort="Medina, Monique" uniqKey="Medina M" first="Monique" last="Médina">Monique Médina</name><name sortKey="Rio, Jean Paul" sort="Rio, Jean Paul" uniqKey="Rio J" first="Jean-Paul" last="Rio">Jean-Paul Rio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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